Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients
نویسندگان
چکیده
منابع مشابه
Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients
Huntington's disease (HD) is an inherited neurodegenerative disorder typified by involuntary body movements, and psychiatric and cognitive abnormalities. Many HD patients also exhibit metabolic changes including progressive weight loss and appetite dysfunction. Here we have investigated metabolic function in pre-manifest and manifest HD subjects to establish an HD subject metabolic hormonal pla...
متن کاملExtracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease
BACKGROUND Alterations in extracellular vesicles (EVs), including exosomes and microparticles, contribute to cardiovascular disease. We hypothesized that obesity could favour enhanced release of EVs from adipose tissue, and thereby contribute to cardiovascular risk via obesity-induced metabolic complications. The objectives of this study were: 1) to investigate the relation between the quantity...
متن کاملCancer risk in patients with manifest vascular disease: effects of smoking, obesity, and metabolic syndrome.
BACKGROUND Patients with vascular disease may be at increased risk of cancer because of shared risk factors and common pathogenesis. METHODS Patients with vascular disease (n = 6,172) were prospectively followed for cancer incidence. Standardized incidence ratios (SIRs) were calculated to compare the cancer incidence of the study population with that of the general population. Multivariable-a...
متن کاملManifest Destiny and American Identity in Cormac McCarthy’s Blood Meridian
McCarthy scholarship has predominantly tended to stress the writer’s revisionism with regard to his rendering of the myth of the American West in Blood Meridian (1985). McCarthy’s novel has beenmainlyhailed as a critique of the violence of manifest destiny. This study aims to delineate aspects of McCarthy’s narrative which resist the predominant view of him as a revisionist. In this re...
متن کاملSilent brain infarcts in patients with manifest vascular disease.
BACKGROUND AND PURPOSE Silent infarcts are frequently found on MRIs of brains of healthy elderly persons (aged >60 years). The purpose of this study was to investigate the prevalence and determinants of silent infarcts in a population of patients with clinically manifest vascular disease. METHODS To detect silent infarcts, MR images were made in 308 participants of the Second Manifestations o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2014
ISSN: 1664-042X
DOI: 10.3389/fphys.2014.00231